Over 1,000 Peer-Reviewed Scientific Articles

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Every day, water containing dissolved molecular hydrogen is used in clinical trials, research laboratories, and medical facilities around the world. To date, over 1,000 peer-reviewed scientific articles and clinical studies on the benefits of molecular hydrogen have been published.

Around the globe, scientists believe that molecular hydrogen has the potential to improve medical endpoints and alter the course of serious medical conditions.

Here’s one more key takeaway: Tyent Water Ionizers are still the only water ionizer machines on the market that are proven to produce alkaline water containing molecular hydrogen.

1. Akhavan, O., et al., Hydrogen-rich water for green reduction of graphene oxide suspensions. International Journal of Hydrogen Energy, 2015. 40(16): p. 5553-5560.

2. Berjak, P., et al., Cathodic amelioration of the adverse effects of oxidative stress accompanying procedures necessary for cryopreservation of embryonic axes of recalcitrant-seeded species. Seed Science Research, 2011. 21(3): p. 187-203.

3. Hanaoka, K., Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions. Journal of Applied Electrochemistry, 2001. 31(12): p. 1307-1313.

4.Hanaoka, K., et al., The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis. Biophysical Chemistry, 2004. 107(1): p. 71-82.

5.Hiraoka, A., et al., In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives. Journal of Health Science, 2010. 56(2): p. 167-174.

6.Hiraoka, A., et al., Studies on the properties and real existence of aqueous solution systems that are assumed to have antioxidant activities by the action of “active hydrogen”‘. Journal of Health Science, 2004. 50(5): p. 456-465.

7.Kato, S., D. Matsuoka, and N. Miwa, Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2, 2′-bipyridyl methods. Materials Science and Engineering:, 2015. C 53: p. 7-10.

8.Lee, M.Y., et al., Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein. Appl Biochem Biotechnol, 2006. 135(2): p. 133-44.

9.Ohsawa, I., et al., Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007. 13(6): p. 688-694.

10.Ohta, S., Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. Methods Enzymol, 2015. 555: p. 289-317.

11.Park, E.J., et al., Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA. Journal of the Korean Society for Applied

Biological Chemistry, 2005. 48(2): p. 155-160.

12.Park, S.K., et al., Electrolyzed-reduced water confers increased resistance to environmental stresses. Molecular & Cellular Toxicology, 2012. 8(3): p. 241-247.

13.Park, S.K. and S.K. Park, Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans. Biol Res, 2013. 46(2): p. 147-52.

14.Penders, J., R. Kissner, and W.H. Koppenol, ONOOH does not react with H2. Free Radic Biol Med, 2014.

15.Qian, L., et al., Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). Transplantation, 2013. 95(5): p. 658-62.

16.Shi, Q.H., et al., Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment. Biomed Environ Sci, 2015. 28(3): p. 239-41.

17.Shirahata, S., et al., Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochemical and Biophysical Research Communications, 1997. 234(1): p. 269-274.

18.Yan, H., et al., Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water–participation of Pt nanoparticles. Bioscience, Biotechnology, and Biochemistry, 2011. 75(7): p. 1295-9.

19.Yan, H., et al., electrolyzed reduced water prolongs Caenorhabditis elegans lifespan, in Animal Cell Technology: Basic & Applied Aspects. 2010, Springer Netherlands. p. 289-293.

20.Yan, H.X., et al., Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water. Bioscience Biotechnology and Biochemistry, 2010. 74(10): p. 2011-2015.

21.Yanagihara, T., et al., Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats. Biosci Biotechnol Biochem, 2005. 69(10): p. 1985-7.

22.Cai, W.W., et al., Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem, 2013. 373(1-2): p. 1-9.

23.Fujita, R., et al., Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. Journal of Physiological Anthropology, 2011. 30(5): p. 195-201.

24.Guo, J.D., et al., Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol, 2013. 168(6): p. 1412-20.

25.Hanaoka, T., et al., Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research, 2011. 1(1): p. 18.

26.Itoh, T., et al., Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and Biophysical Research Communications, 2011. 411(1): p. 143-9.

27.Kawasaki, H., J.J. Guan, and K. Tamama, Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochemical and Biophysical Research Communications, 2010. 397(3): p. 608-613.

28.Kubota, M., et al., Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Investigative Ophthalmology and Visual Science, 2011. 52(1): p. 427-33.

29.Lekic, T., et al., Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl, 2011. 111: p. 237-41.

30.Li, D.Z., et al., Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab, 2013.

31.Sun, Y., et al., Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int, 2013. 24(3): p. 969-78.

32.Takeuchi, S., et al., Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Internal Medicine, 2012. 51(11): p. 1309-13.

33.Xu, Z., et al., Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond), 2012. 9: p. 2.

34.Yuan, L., et al., Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation. Med Sci Monit, 2015. 21: p. 749-54.

35.Bari, F., et al., Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. Stroke, 2010. 41(4): p. E323-E323.

36.Cui, Y., et al., Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Surg Res, 2014.

37.Dohi, K., et al., Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury. PLoS One, 2014. 9(9): p. e108034.

38.Domoki, F., et al., Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research, 2010. 68(5): p. 387-392.

39.Eckermann, J.M., et al., Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research, 2011. 1(1): p. 7.

40.Feng, Y., et al., Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res, 2013. 38(3): p. 396-404.

41.Fu, Y., et al., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters, 2009. 453: p. 81–85.

42.Fujita, K., et al., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One, 2009. 4(9): p. e7247.

43.Gu, Y., et al., Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition, 2010. 46(3): p. 269-276.

44.Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.

45.Hong, Y., et al., Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res, 2012. 90(8): p. 1670-80.

46.Hong, Y., et al., Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One, 2014. 9(4): p. e96212.

47.Hou, Z., et al., Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull, 2012. 88(6): p. 560-5.

48.Huang, G., et al., The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation, 2013. 84(5): p. 690-5.

49.Hugyecz, M., et al., Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research, 2011. 1404: p. 31-8.

50.Ito, M., et al., Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res, 2012. 2(1): p. 15.

51.Ji, X., et al., Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 2010. 1354: p. 196-205.

52.Ji, X., et al., Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research, 2012. 178(1): p. e9-16.

53.Kashiwagi, T., et al., Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics, 2005. 2: p. 257-260.

54.Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev, 2014. 2014: p. 869121.

55.Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): p. A64-A64.

56.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.

57.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research, 2011. 71: p. E406-E406.

58.Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.

59.Liu, F.T., et al., Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther, 2014.

60.Liu, L., et al., Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res, 2014. 1589: p. 78-92.

61.Liu, W., et al., Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl, 2011. 111: p. 307-11.

62.Manaenko, A., et al., Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl, 2011. 111: p. 179-83.

63.Manaenko, A., et al., Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Critical Care Medicine, 2013. 41(5): p. 1266-75.

64.Mano, Y., et al., Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med, 2014. 69: p. 324-30.

65.Matsumoto, A., et al., Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep, 2013. 3: p. 3273.

66.Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.

67.Nagata, K., et al., Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology, 2009. 34(2): p. 501-508.

68.Olah, O., et al., Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology, 2013. 104(2): p. 79-86.

69.Ono, H., et al., Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 2011. 1(1): p. 12.

70.Ostojic, S.M., Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacol Res, 2015. 94: p. 51-3. (brain)

71.Pshenichnyuk, S.A. and A.S. Komolov, Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H2 Antioxidant Species Inside Mitochondria. The Journal of Physical Chemistry Letters, 2015. 6(7): p. 1104-1110.

72.Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008. 375(3): p. 346-350.

73.Shen, L., et al., Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical Research, 2011. 36(8): p. 1501-11.

74.Shen, M.H., et al., Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther, 2013. 19(5): p. 361-3.

75.Spulber, S., et al., Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One, 2012. 7(7): p. e42078.

76.Sun, Q., et al., Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine, 2011. 39(4): p. 765-9.

77.Takeuchi, S., et al., Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci, 2015. 16(1): p. 22. (brain)

78.Ueda, Y., A. Nakajima, and T. Oikawa, Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochemical Research, 2010. 35(10): p. 1510-1515.

79.Wang, C., et al., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neuroscience Letters, 2011. 491(2): p. 127-32.

80.Wang, T., et al., Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol, 2014.

81.Wang, W., et al., Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research, 2012. 34(10): p. 1007-15.

82.Xie, F. and X. Ma, Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders. Brain Disord Ther, 2014: p. 2.

83.Yan, H., et al., The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P69.

84.Yamada, T., et al., Hydrogen supplementation of preservation solution improves viability of osteochondral grafts. ScientificWorldJournal, 2014. 2014: p. 109876. (bones)

85.Yokoi, I., Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research, 2010. 68: p. E320-E320.

86.Zhan, Y., et al., Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine, 2012. 40(4): p. 1291-6.

87.Zhang, L., et al., Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull, 2014. 106C: p. 47-55.

88.Zhou, J., et al., Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research, 2012. 178(1): p. 390-400.

89.Zhuang, Z., et al., Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res, 2013. 91(12): p. 1599-608.

90.Zhuang, Z., et al., Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci, 2012. 13: p. 47.

91.Akio Kagawa, K.K., Masayuki Mizumoto, Yutaka Tagawa, Yoichi Masiko, Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum, 2012. 706: p. 520-525.

91.Asada, R., et al., Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep, 2010. 24(6): p. 1463-70.

92.Chen, Y., et al., On the antitumor properties of biomedical magnesium metal. Journal of Materials Chemistry B, 2015. 3(5): p. 849-858.

93.Dole, M., F.R. Wilson, and W.P. Fife, Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 1975. 190(4210): p. 152-4.

94.Jun, Y., et al., Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water. In Vitro Cellular & Developmental Biology-Animal, 2004. 40: p. 79A-79A.

95.Kinjo, T., et al., Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. Cytotechnology, 2012. 64(3): p. 357-371.

96.Komatsu, T., Katakura, Y., Teruya, K., Otsubo, K., Morisawa, S., & and S. Shirahata, Electrolyzed reduced water induces differentiation in K-562 human leukemia cells. Animal cell technology: Basic & applied aspects, 2003: p. 387-391.

97.LEE, K.-J., et al., Anticancer Effect of Alkaline Reduced Water. J Int Soc Life Inf Sci, 2004. 22(2): p. 302-305.

98.Matsushita, T., et al., Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Jpn J Radiol, 2011. 29(7): p. 503-12.

99.Matsuzaki, M., et al., Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy, in Materials Science and Chemical Engineering 2013. p. 284-290.

100.Motoishi, A., et al., Influence of Active Hydrogen Discharged from Palladium-Nickel Alloy Powder on Biological Cells. Advanced Materials Research, 2013. 669: p. 273-278.

101.Nakanishi, K., et al., growth suppression of HL60 and L6 cells by atomic hydrogen, in Animal Cell Technology: Basic & Applied Aspects, . 2010, Springer Netherlands. p. 323-325.

102.Nakashima-Kamimura, N., et al., Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol, 2009.

103.Nan, M., C. Yangmei, and Y. Bangcheng, Magnesium metal-A potential biomaterial with antibone cancer properties. J Biomed Mater Res A, 2014. 102(8): p. 2644-51.

104.Nishikawa, H., et al., Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum nanoparticles, in Animal Cell Technology: Basic & Applied Aspects. 2006, Springer Netherlands. p. 113-119.

105.Nishikawa, R., et al., Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation. Cytotechnology, 2005. 47(1-3): p. 97-105.

106.Nishikawa, R., et al., Suppression of two-stage cell transformation by electrolyzed reduced water/platinum nanocolloids. In Vitro Cellular & Developmental Biology-Animal, 2004. 40: p. 79A-79A.

107.Roberts, B.J., et al., Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen. Cancer Treat Rep, 1978. 62(7): p. 1077-9.

108.Runtuwene, J., et al., Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ, 2015. 3: p. e859.

109.Shirahata, S.K., K. Kusumoto, M. Gotoh, K. Teruya, K. Otsubo, J. S. Morisawa, H. Hayashi, K. Katakura, Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Suppresses Cell Growth and Regulates Gene Expression of Animal Cells. New Developments and New Applications in Animal Cell Technology, 2002: p. 93-96.

110.Saitoh, Y., et al., Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression. Oncology Research, 2008. 17(6): p. 247-255.

111.Saitoh, Y., et al., Platinum nanocolloid-supplemented hydrogen dissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Exp Oncol, 2009. 31(3): p. 156-62.

112.Tsai, C.F., et al., Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione. Biosci Biotechnol Biochem, 2009. 73(2): p. 280-7.

113.Ye, J., et al., Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & Pharmaceutical Bulletin, 2008. 31(1): p. 19-26.

114.Chen, L., et al., Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. PLoS One, 2014. 9(6): p. e100774.

115.Feng, M., et al., Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol, 2012. 5(2): p. 151-7.

116.Huang, L., et al., Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res, 2012. 47(3): p. 122-7.

117.Kashiwagi, T., et al., Suppression of glutamate-induced neural cell death by electrolyzed-reduced water, in Animal Cell Technology: Basic & Applied Aspects. 2004, Springer Netherlands. p. 105-109.

118.Kikkawa, Y.S., et al., Hydrogen protects auditory hair cells from free radicals. Neuroreport, 2009. 20(7): p. 689-94.

119.Kurioka, T., et al., Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res, 2014.

120.Lin, Y., et al., Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neuroscience Letters, 2011. 487(1): p. 12-16.

121.Moossavi, A., F. Bagheri, and H.R. Farkhani, Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss. Rehabilitation Medicine 2014. 2(4).

122.Oharazawa, H., et al., Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Investigative Ophthalmology & Visual Science, 2010. 51(1): p. 487-492.

123.Qu, J., et al., Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacologica Sinica, 2012. 33(4): p. 445-451.

124.Qu, J., et al., Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol, 2012. 76(1): p. 111-5.

125.Sun, J.C., et al., Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One, 2014. 9(6): p. e99299.

126.Taura, A., et al., Hydrogen protects vestibular hair cells from free radicals. Acta Oto-Laryngologica, 2010. 130: p. 95-100.

127.Tian, L., et al., Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. Med Gas Res, 2013. 3(1): p. 19.

128.Xiao, X., et al., Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. Journal of Ocular Pharmacology and Therapeutics, 2012. 28(1): p. 76-82.

129.Yang, C.X., H. Yan, and T.B. Ding, Hydrogen saline prevents selenite-induced cataract in rats. Molecular Vision, 2013. 19: p. 1684-93.

130.Yokota, T., et al., Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experiment Ophthalmol, 2015.

131.Zhou, Y., et al., Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neuroscience, 2012. 209: p. 47-53.

132.Aoki, K., et al., Is hydrogen gas in water present as bubbles or hydrated form? Journal of Electroanalytical Chemistry, 2012. 668: p. 83-89.

133.Black, J.H., Chemistry and cosmology. Faraday Discussions, 2006. 133: p. 27-32; discussion 83-102, 449-52.

134.Buxton, G.V., et al., Critical view of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (•OH/•OH–) in aqueous solution. J Phys Chem Ref Data, 1988. 17: p. 513-886.

135.Choi, W.K., Investigations of Quantitative Reducibility Determination and Reducibility Variations of Neutral Hydrogen-Dissolved Water by Electrochemical Analysis. Int. J. Electrochem. Sci, 2014. 9: p. 7266-7276.

136.Donald, W.A., et al., Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy. Chemistry, 2009. 15(24): p. 5926-34.

137.Ehrenfreund, P., et al., Astrophysical and astrochemical insights into the origin of life. Reports on Progress in Physics, 2002. 65(10): p. 1427-1487.

138.Hamasaki, T., et al., Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles. Langmuir, 2008. 24(14): p. 7354-64.

139.Huber, C. and G. Wachtershauser, alpha-Hydroxy and alpha-amino acids under possible Hadean, volcanic origin-of-life conditions. Science, 2006. 314(5799): p. 630-2.

140.Jain, I.P., Hydrogen the fuel for 21st century. International Journal of Hydrogen Energy,2009 34(17): p. 7368-7378.

141.Kikuchi, K., et al., Characteristics of hydrogen nanobubbles in solutions obtained with water electrolysis. Journal of Electroanalytical Chemistry, 2007. 600(2): p. 303-310.

142.Kikuchi, K., et al., Hydrogen particles and supersaturation in alkaline water from an Alkali-Ion-Water electrolyzer. Journal of Electroanalytical Chemistry, 2001. 506(1): p. 22-27.

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355.Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.

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359.Liu, G.D., et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.

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362.Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc, 2014. 46(4): p. 1104-6.

363.Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.

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371.Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.

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385.Liu, S.L., et al., Hydrogen Therapy may be a Novel and Effective Treatment for COPD. Front Pharmacol, 2011. 2: p. 19.

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401.Zhang, J., et al., Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol, 2014. 21(1): p. 94-101.

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402.Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects. S. Netherlands, Editor. 2010. p. 315-321.

403.Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).

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407.Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.

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412.Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. Journal of Urology, 2013. 190(1): p. 350-6.

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440.Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 2011. 12: p. 26.

441.Wang, Q.J., et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl), 2012. 125(9): p. 1633-7.

442.Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta, 2011. 32(9): p. 681-6.

443.Yeunhwa GU, K.O., Taigo FUj, Yuka ITOKAWA, et al., Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology, 2006. 150(11): p. 384-392.

444.Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.

445.Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem, 2012. 365(1-2): p. 233-42.

446.Zheng, H. and Y.S. Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.

447.Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.

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449.Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015.

450.Chen, Q., et al., Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci, 2013. 40(6): p. 857-63.

451.Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One, 2014. 9(5): p. e97436.

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453.Kawaguchi, M., et al., Molecular hydrogen attenuates neuropathic pain in mice. PLoS One, 2014. 9(6): p. e100352.

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486.Watanabe, T., et al., Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in rats. J Toxicol Sci, 1998. 23(5): p. 365-71.

487.Watanabe, T., et al., Histopathological influence of alkaline ionized water on myocardial muscle of mother rats. J Toxicol Sci, 1998. 23(5): p. 411-7.

488.Watanabe, T., et al., Influences of alkaline ionized water on milk electrolyte concentrations in maternal rats. J Toxicol Sci, 2000. 25(5): p. 417-22.

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490.Yamagishi, Y., et al., Hepatotoxicity of sub-nanosized platinum particles in mice. Pharmazie, 2013. 68(3): p. 178-82.

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493.Buchholz, B.M., et al., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 2008. 8(10): p. 2015-2024.

494.Buchholz, B.M., et al., Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation, 2011. 92(9): p. 985-92.

495.Chen, H.G., et al., Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg, 2013. 11(10): p. 1060-6.

496.He, J., et al., Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 2013(0).

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498.Jin, Y., et al., Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration. Med. Hypotheses Res, 2011. 7: p. 43-47.

499.Kajiya, M., et al., Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun, 2009: p. in press.

500.Li, G.M., et al., Effects of hydrogen-rich saline treatment on polymicrobial sepsis. Journal of Surgical Research, 2013. 181(2): p. 279-86.

501.Liu, X., et al., The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol, 2012. 13(2): p. 197-203.

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503.Naito, Y., et al., Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. Journal of Clinical Biochemistry and Nutrition, 2002. 32: p. 69-81.

504.Nishimura, N., et al., Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats. J Nutr, 2013. 143(12): p. 1943-9.

505.Pilcher, J.E., Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas. Annals of Surgery, 1888. 8(3): p. 190-204.

506.Senn, N., RECTAL INSUFFLATION OF HYDROGEN GAS AN INFALLIBLE TEST IN THE DIAGNOSIS OF VISCERAL INJURY OF THE GASTRO INTESTINAL CANAL IN PENETRATING WOUNDS OF THE ABDOMEN. Read in the Section on Surgery, at the Thirty-ninth Annual Meeting of the American Medical Association, May, 9, 1888, and illuistrated by three experiments on dogs.”. JAMA: Journal of the American Medical Association, 1888. 10(25): p. 767-777.

507.Sheng, Q., et al., Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg, 2013. 48(8): p. 1697-706.

508.Shigeta, T., et al., Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation, 2015. 99(3): p. 500-7.

509.Vorobjeva, N.V., Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. Med Hypotheses, 2005. 64(3): p. 543-6.

510.Xie, K.L., et al., [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(5): p. 454-7.

511.Xie, K.L., et al., Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock, 2010. 34(1): p. 90-97.

512.Xie, K., et al., Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock, 2012. 38(6): p. 656-63.

513.Xie, K., et al., Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia, 2012. 108(3): p. 538-539.

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515.Xue, J., et al., Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complementary and Alternative Medicine, 2014. 14(1): p. 81.

516.Zhang, J.Y., et al., Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol, 2014. 20(6): p. 1614-22.

517.Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.

518.Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.

519.Guo, S.X., et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p. e0124897.

520.Ignacio, R.M., et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med, 2013. 2013: p. 538673.

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522.Jiang, Z., et al., Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol, 2013. 112(3): p. 186-91.

523.Kato, S., et al., Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B, 2012. 106: p. 24-33.

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525.Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.

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Functional Water For Prevention and Treatment of Diseases

Molecular Hydrogen & Weight Loss - 1

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Alkaline Reduced Water Enhances Time To Exhaustion During Lactate Threshold Running

Changes in ORP as a Function of pH and Hydrogen Gas Concentration

Natural Molecular Hydrogen in Every Glass of Tyent Water

Every glass of alkaline water from a Tyent Water Ionizer contains thousands of bubbles of naturally occurring molecular hydrogen.  Only Tyent can make this claim. Tyent water ionizers are unique within the industry as the only water ionizer machines that are proven to produce molecular hydrogen-rich alkaline water.

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